Humans are the main characters of almost all Sega Superstars comics, primarily starring as the heroes:
- Shinobi - every speaking character
- The Legend of the Golden Axe - every named character apart from Rigia Mortius and possibly Gilius-Thunderhead and other dwarves.
- Wonder Boy - the inhabitants of Monster World and the Skyrock Mountains
- Streets of Rage - everyone
- Kid Chameleon - Casey, Suzi, Brad and several supporting characters in both the real world and Wildside.
- Decap Attack - Professor Frank N. Stein and almost all supporting characters. Igor is probably one.
- Eternal Champions - most characters, except Trident.
- Pirate S.T.C. - all of the heroes (except Dog) and Fezhead. The humanity of the video game characters is questionable.
- Mutant League - Brenda Brikka, Doctor Wizz, Bob Chong and Chuck Tempest.
- Marko's Magic Football - everyone not coated in green slime or a robot.
- Shining Force - Bowie, Maximillian and all supporting characters.
- Shenmue - everyone
- House of the Dead - everyone that isn't a zombie.
- Panzer Dragoon - everyone that isn't a dragon.
In the universe of Sonic the Hedgehog, there were very few humans in the early days. It was revealed in Sonic the Comic Online that Doctor Kintobor was doing some shopping on Earth until he took a wrong turn and ended up in the Emerald Hill Zone. Thus, Kintobor became the first human on Mobius. In turn, Doctor Robotnik became the only human left on Mobius.
During their adventures through time and space, Amy Rose and Tekno the Canary made contact with other humans for the first time, but did not enjoy the experience. Professor Cratermass was their first encounter and talked slow, believing the aliens would not understand him otherwise. He then was required to help the girls fight Colonel Granite, leader of Operation Starwatch, and help them return to Mobius. Granite would show up again in 1860s Kansas, bringing his own robots to a primitive time in order to take control. As part of their duties, Amy and Tekno ended those hopes but inadvertantly gave Granite the co-ordinates to Mobius. Granite's final act was to invade Mobius and attempt to rename it "Planet Percy". To stop him, Sonic visited Earth and had talks with the Prime Minister of the United Kingdom who pointed him to Granite's Scotland base. The combined powers of Sonic and Nature itself sent Granite's men back to Earth, where they were arrested by the Military Police.
Other humans have appeared on Mobius, although perhaps by mistake. Thomas & Miller were lackeys of Robotnik who heavily resembled humans, while The Chiller held the Pleasant Zone in his icy grasp. Elsewhere, soldiers who looked like humans fought the monster Medusa on Shanazar.